PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4095)
Related Products (4095)
-
PROTAC Linkers Isoform Comparison
-
2-(4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)phenyl)acetic acid
0 ImagesCat. No.: HY-W095751CAS No.: 176504-01-1
-
N-Fmoc-8-aminooctanoic acid
0 ImagesN-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
-
tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate
0 ImagesCat. No.: HY-W019276CAS No.: 152537-03-6
-
tert-Butyl 2-oxo-6-azaspiro[3.4]octane-6-carboxylate
![tert-Butyl 2-oxo-6-azaspiro[3.4]octane-6-carboxylate](https://file.medchemexpress.com/product_pic/hy-w043794.gif "Click to View tert-Butyl 2-oxo-6-azaspiro[3.4]octane-6-carboxylate Product Detail")
0 ImagesCat. No.: HY-W043794CAS No.: 203661-71-6
-
Undec-10-yn-1-ol
0 ImagesCat. No.: HY-W088475CAS No.: 2774-84-7
-
3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid
![3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w059484.gif "Click to View 3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid Product Detail")
0 ImagesCat. No.: HY-W059484CAS No.: 83249-08-5
![8-Boc-8-Azaspiro[4.5]decane-2-amino](https://file.medchemexpress.com/product_pic/hy-w063826.gif "Click to View 8-Boc-8-Azaspiro[4.5]decane-2-amino Product Detail")
![2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.5]nonan-7-yl)acetic acid](https://file.medchemexpress.com/product_pic/hy-w539683.gif "Click to View 2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.5]nonan-7-yl)acetic acid Product Detail")
-
[(5-Bromopentyl)oxy](tert-butyl)dimethylsilane
dimethylsilane](https://file.medchemexpress.com/product_pic/hy-w108844.gif "Click to View [(5-Bromopentyl)oxy](tert-butyl)dimethylsilane Product Detail")
0 ImagesCat. No.: HY-W108844CAS No.: 85514-43-8
-
6-Chloro-1-hexyne
0 ImagesSynonyms: 5-Hexynyl Chloride
-
9-Aminononanoic acid
0 ImagesCat. No.: HY-W105727CAS No.: 1120-12-39-Aminononanoic acid can be used as a PROTAC linker and other conjugation in the synthesis of PROTACs. 9-Aminononanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
-
1-(Piperidin-4-yl)azetidin-3-ol
0 ImagesCat. No.: HY-W061856CAS No.: 1147423-04-8
-
3-(Piperidin-4-yl)propan-1-ol
0 ImagesCat. No.: HY-W002891CAS No.: 7037-49-2
-
endo-BCN-PEG2-NHS ester
0 ImagesCat. No.: HY-140067CAS No.: 2243565-12-8
-
Boc-NH-PEG2-C2-NHS ester
0 ImagesCat. No.: HY-141117CAS No.: 2183440-73-3
-
Br-PEG4-CH2-Boc
0 ImagesCat. No.: HY-130536CAS No.: 1807505-29-8
-
tert-Butyl 9-aminononanoate
0 ImagesCat. No.: HY-W248248CAS No.: 134857-22-0
-
Thiol-C2-PEG2-OH
0 ImagesCat. No.: HY-135085CAS No.: 56282-36-1
